Effects of Achillea Millefolium Extract on Spontaneous and Oxytocin-Induced Isolated Rat Uterine Contractions

Achillea millefolium (AM) is widely used in traditional medicine a wide geography due to its effects on the female reproductive system. However, effect uterine smooth muscle contractions unknown. Our study aims investigate of AM spontaneous and oxytocin-induced isolated rat contractions. Myometrial strips were obtained from 32 adult Wistar Albino rats. Contraction amplitudes frequencies recorded after either following: administration only Krebs-Hanseleit (KBH) solution, extract (AME); KBH or AME inducing with oxytocin. When was administered at dose 2mg/ml, it significantly reduced (non-induced) contraction frequency compared control group addition medium (AME: 2.37±0.49, KBH: 9.25±1.69, p=0.002). amplitude administrations 0.5, 1, 2mg/ml (p